Fig. S4

Quantification of the Sbds^ATG morphant phenotype with concomitant knockdown of p53. (A) Quantification of multiple independent experiments scored for wild-type pancreatic development at 72 hpf in p53^ATG MO-injected embryos. (B) Quantification of three independent experiments scored for mpo-positive cells in the intermediate cell mass (ICM) at 24 hpf. (C) Disrupted cartilage persists in p53^ATG/Sbds^ATG MO-injected embryos at 72 hpf (blue). (D) Quantification of three independent experiments scored for percentage of embryos exhibiting wild-type ceratohyal development at 72 hpf. (E) Quantification of three independent experiments scored for the fraction of embryos with wild-type pancreas in Sbds^ATG and p53^Spl MO-injected ptf1a:eGFP;ins:mCherry embryos at 72 hpf. (F) Injection of the p53^Spl MO causes an 89 bp shift and destabilization in p53 mRNA. ch, cerotohyal cartilage.