FIGURE

Fig. 3

ID

ZDB-FIG-120810-57

Publication

Lee et al., 2012 - Disruption of the folate pathway in zebrafish causes developmental defects

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Fig. 3

Methotrexate treatment confers dose-dependent developmental delay. A) Treatment with lower concentrations of MTX causes shortening of the anterior-posterior axis and heart defects, while higher doses result in embryonic lethality prior to somitogenesis. B) Defects evident at 2 dpf in embryos treated with 200 μM methotrexate are alleviated by treatment with 10 mM Folinic Acid (FA). Embryos in lateral view.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.