FIGURE
Fig. 6
- ID
- ZDB-FIG-120525-7
- Publication
- Mattes et al., 2012 - Wnt3 and Wnt3a are required for induction of the mid-diencephalic organizer in the caudal forebrain
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Fig. 6
Blockage of Wnt signaling lead to lack of MDO tissue. Lateral views and dorsal views (marked by ′) of embryonic heads at 28 hpf. Wnt3/wnt3a morphant embryos lack the organizer tissue and the lhx5 positive prethalamus (PTh, blue) abuts the irx1b thalamus (Th, red) (A-B′, n = 54/78). A similar phenotype is observed in embryos treated with 30 μM IWR1 from 10 to 28 h to inhibit canonical Wnt signaling (n = 15/17). Hence, the otx2 positive MDO (yellow) is lacking if Wnt3/Wnt3a function is knocked-down (n = 44/80, D-E′), likewise after inhibition of canonical Wnt signaling (F, F′, n = 14/24). |
Expression Data
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| Anatomical Terms: | |
| Stage: | Prim-5 |
Expression Detail
Antibody Labeling
Phenotype Data
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| Condition: | |
| Knockdown Reagents: | |
| Observed In: | |
| Stage: | Prim-5 |
Phenotype Detail
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