FIGURE

Fig. 8

ID

ZDB-FIG-120330-8

Publication

Tu et al., 2012 - Zebrafish arl6ip1 Is Required for Neural Crest Development during Embryogenesis

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Fig. 8

Cell death does not cause the loss of neural crest cells.

Lateral views of TUNEL-labeled wild-type (WT) embryos (A-C) or arl6ip1-MO1-injected embryos (D-F) at 3-somite stage (A, D), 8-somite stage (B, E), and 15-somite stage (C, F), respectively. (A, D) There were no TUNEL-positive cells in WT and arl6ip1-MO1 embryos. (B, C, E, F) Compared to WT embryos, arl6ip-deficient embryos displayed a significant increase of TUNEL-positive cells in the dorsal region of embryos at the 8- and 15-somite stages (indicated by arrowheads) (B and C vs. E and F). (G, H, I) Double-labeling analysis with crestin (dark blue) and TUNEL (red fluorescent) showed that only limited cell death occurred at the expression region of crestin. (G′, H′, I′) The views of the embryos shown in panels G′, H′ and I′ were at higher magnification.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-arl6ip1 AB + MO1-arl6ip1 + MO4-tp53
Knockdown Reagents:	MO1-arl6ip1 MO4-tp53
Observed In:	apoptotic process neural crest cell neural crest cell apoptotic process
Stage Range:	1-4 somites to 14-19 somites

Phenotype Detail

Acknowledgments

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