FIGURE

Fig. 5

ID

ZDB-FIG-120330-5

Publication

Tu et al., 2012 - Zebrafish arl6ip1 Is Required for Neural Crest Development during Embryogenesis

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Fig. 5

The markers of pre-migratory neural crest cells are down-regulated in arl6ip1-MO1-injected embryos.

Dorsal views of 3-somite-stage wild-type (A, B, C, D) and arl6ip1 knockdown embryos (E, F, G, H), or 8-somite-stage wild-type (I, J, K,) and arl6ip1 knockdown embryos (L, M, N) were shown to reveal the indicated markers. Neural plate border was indicated with the expression of tfap2α (A, E), foxd3 (B, F), snai1b (C, G) and sox10 (D, H). Decreased expression of these markers, except tfap2α, was evident and predominant in arl6ip1 morphants. Arrows indicate position of midbrain-hindbrain boundary. (I-K) At the 8-somite stage, these markers were expressed predominantly in early migrating cranial neural crest cells (indicated by brackets). (L-N) These genes were reduced in embryos co-injected with 4 ng arl6ip1-MO1/6 ng p53-MO, especially in foxd3 and snai1b expression.

Expression Data

Genes:	foxd3 snai1b sox10 tfap2a
Fish:	AB AB + MO1-arl6ip1 AB + MO1-arl6ip1 + MO4-tp53
Knockdown Reagents:	MO1-arl6ip1 MO4-tp53
Anatomical Terms:	cranial neural crest cell neural crest
Stage Range:	1-4 somites to 5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-arl6ip1 AB + MO1-arl6ip1 + MO4-tp53
Knockdown Reagents:	MO1-arl6ip1 MO4-tp53
Observed In:	cranial neural crest
Stage Range:	1-4 somites to 5-9 somites

Phenotype Detail

Acknowledgments

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