FIGURE

Fig. 3

ID

ZDB-FIG-111014-3

Publication

Valdivia et al., 2011 - Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development

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Fig. 3

Primordium organisation, neuromast morphology and differentiation are unaffected by loss of Lef1 function. (A-L) Expression of fgf3 (A-D), pea1 (E-H) and sef1 (I-L) in wild type (A,B,E,F,I,J) and lef1^u767 mutants (C,D,G,H,K,L). Primordia are outlined. (M,N) Tg(-8.0cldnb:lynEGFP)^zf106-labelled wild-type (M) and lef1^u767 (N) primordia at 38 hpf. Membrane-anchored GFP reveals the polarisation of cells and their organisation into rosettes (arrows). (O,P) The last-deposited neuromast in a lef1^u767 mutant (P) and wild type (O) labelled with anti-acetylated tubulin antibody (green). Nuclei are DAPI stained. Scale bar: 20 μm. (Q,R) Diasp staining in wild type (Q) and lef1^u767mutant (R) at 3 dpf. DAPI-labelling of nuclei (inset in R) shows no more neuromasts in the lef1^u767 other than those labelled with Diasp).

Expression Data

Genes:	EGFP etv4 fgf3 il17rd
Antibody:	Ab1-tuba
Fish:	WT lef1^u767/u767 zf106Tg lef1^u767/u767; zf106Tg
Anatomical Terms:	neuromast posterior lateral line primordium
Stage Range:	Prim-15 to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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