FIGURE

Fig. 6

ID

ZDB-FIG-110608-5

Publication

Chung et al., 2011 - Zebrafish her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis

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Fig. 6

Increased neuronal precursors in Her8a knockdown embryos.

Proneural genes were upregulated in the morpholino injected embryos and this effect was rescued by co-injection with her8a mRNA. Proneuronal markers neurogenin1 (A–C) and zash1 (D–F) were analyzed by in situ hybridization. Embryos were injected with control morpholino (A and D), 8 ng of MO2 (B and E), or co-injection of 8 ng of MO2 with 480 pg her8a mRNA (C and F). The most dramatic phenotypes are indicated by arrows. Stages of embryos are 6-somite stage (A-C) and 16-somite stage (D–F). (G) qPCR analysis showing the levels of neurogenin1 and zash1 are both significantly increased in embryos injected with her8a morpholino. * p<0.05.

Expression Data

Genes:	ascl1a neurog1
Fish:	TU TU + MO2-her8a
Knockdown Reagent:	MO2-her8a
Anatomical Term:	central nervous system
Stage Range:	5-9 somites to 14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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