FIGURE

Fig. S1

ID

ZDB-FIG-110224-15

Publication

Dal-Pra et al., 2011 - FoxA transcription factors are essential for the development of dorsal axial structures

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Fig. S1

Abnormal development of the axial structures remaining in partial FoxA2–FoxA3 morphants. Expression of notochord (im:7144261) (A–C) and floor plate markers (foxA2) (D–F) at 24 hpf. (A and B) Transverse sections showing that the notochord is smaller in FoxA2–FoxA3 morphants compared to wild-type, and that some of these cells are mislocated in the ventral neural tube. (C) Position of the transverse section shown in B. (D and E) In FoxA2–FoxA3 morphant, floor plate cells are elongated along the dorso-ventral axis of the neural tube, instead of being cuboidal. (F) Position of the area shown in E. (A and B) Transverse sections, dorsal up. (C–F) Lateral views, anterior to the left.

Expression Data

Genes:	foxa2 im:7144261
Fish:	WT WT + MO1-foxa2 + MO1-foxa3 + MO2-foxa3
Knockdown Reagents:	MO1-foxa2 MO1-foxa3 MO2-foxa3
Anatomical Terms:	floor plate neural tube ventral region notochord
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-foxa2 + MO1-foxa3 + MO2-foxa3
Knockdown Reagents:	MO1-foxa2 MO1-foxa3 MO2-foxa3
Observed In:	floor plate cell notochord cell
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 350(2), Dal-Pra, S., Thisse, C., and Thisse, B., FoxA transcription factors are essential for the development of dorsal axial structures, 484-495, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.