FIGURE

Fig. S3

ID

ZDB-FIG-110214-24

Publication

Tittle et al., 2011 - Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens

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Fig. S3

The dnmt1^s904 allele phenocopies lens defects in uhrf1 mutants. (A) Wild-type and (B) dnmt1^s904 mutant embryos at 5 dpf. As in lenses of uhrf1 and dnmt1^s872 mutant embryos, dnmt1^s904 mutants display obvious lens defects and in the more severely affected embryos lens dysplasias are observed (arrow in B inset). (C,D) Transverse histology from (C) wild-type and (D) dnmt1^s904 mutant embryos at 5 dpf. The mild mutant lens phenotype shown in panel D demonstrates the range of lens defects observed in dnmt1^s904 mutants, which is consistent with the range observed in uhrf1 and dnmt1^s872 mutants. Scale bars are 80 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dnmt1^s904/s904
Observed In:	lens
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 350(1), Tittle, R.K., Sze, R., Ng, A., Nuckels, R.J., Swartz, M.E., Anderson, R.M., Bosch, J., Stainier, D.Y., Eberhart, J.K., and Gross, J.M., Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens, 50-63, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.