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Fig. 9

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ZDB-FIG-110214-21

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Tittle et al., 2011 - Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens

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Fig. 9

Wild-type retinas cannot rescue development of a mutant lens. Lens transplants performed at 37 hpf (Yamamoto and Jeffery, 2002) demonstrate that mutant lenses placed in wild-type retinas retain the mutant phenotype. (A–D) Representative 5 dpf whole-mount and histology data for lens transplants between wild-type embryos and dnmt1 mutants. Each pair of whole-mount and histology images is derived from the same embryo and eye, and transplants were unilateral so control and transplanted lenses are from the same fish. (A,B) dnmt1 lenses transplanted to wild-type host eyes resulted in the mutant phenotype (n = 5). (C,D) Wild-type lenses transplanted to dnmt1 mutant hosts resulted in wild-type lens formation (n = 5). Similar results were obtained from corresponding transplants between uhrf1 mutant and wild-type embryos (data not shown). Scale bars are 80 μm.

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Acknowledgments

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Reprinted from Developmental Biology, 350(1), Tittle, R.K., Sze, R., Ng, A., Nuckels, R.J., Swartz, M.E., Anderson, R.M., Bosch, J., Stainier, D.Y., Eberhart, J.K., and Gross, J.M., Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens, 50-63, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.