FIGURE

Fig. 3

ID

ZDB-FIG-100616-94

Publication

Insinna et al., 2010 - Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development

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Fig. 3

Morpholino knock-down of dync1h1 phenocopies cnb mutants. (A, B) Dorsal views and retinal histology of control (cntl) morpholino (MO) injected (A) and dync1h1 ATG MO injected (B) embryos shown at 3.5 dpf. Note the smaller eyes, expanded melanophores, and photoreceptor dysmorphogenesis. (C) Western blot of wild-type (WT) versus cnb embryos at 3, 4, and 5 dpf (left blot) and wild-type and dync1h1 morphants at 2 dpf (right blot). Each blot was cut and probed with either antisera against human DYNC1H1 (amino-terminal 321 amino acids; top) or gammaTubulin (bottom). Scale bar: 40 μm for retinal histology.

Expression Data

Gene:	dync1h1
Antibody:	Ab1-dync1h1
Fish:	WT dync1h1^mw20/mw20 WT + MO1-dync1h1
Knockdown Reagent:	MO1-dync1h1
Anatomical Term:	whole organism
Stage Range:	Long-pec to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-dync1h1
Knockdown Reagent:	MO1-dync1h1
Observed In:	embryonic retina morphogenesis in camera-type eye eye melanocyte photoreceptor cell morphogenesis
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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