FIGURE

Fig. 1

ID

ZDB-FIG-100616-92

Publication

Insinna et al., 2010 - Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development

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Fig. 1

The cnb mutation disrupts photoreceptor development. (A-D) Side (A, C) and dorsal (B, D) views of 5-dpf wild-type (A, B) and cnb mutant (C, D) embryos. (E-F) Retinal histology of wild-type (E) and cnb (F) retina at 4 dpf. (G, H) Zpr-1 immunoreactivity (brown) to label double cone photoreceptors (PhR) in 4-dpf wild-type (G) and cnb embryos (H). (I, J) ID1 immunoreactivity (brown) to label rod photoreceptors in 4-dpf wild-type (G) and cnb embryos (H). Nuclei in (G, H) are counterstained with methylene blue. (K-N) Confocal microscopy of wild-type (K, M) and cnb (L, N) whole retina (K, L) and individual rod photoreceptor cells (M, N) from Tg(Xlrho:EGFP)^fl1fish. Green, Xlrho:EGFP-positive cells; red, propidium iodide positive nuclei. Scale bars: 1 mm in (A, C); 40 μm in (E-L); 5 μm in (M, N). EGFP, enhanced green fluorescent protein.

Expression Data

Gene:	EGFP
Antibodies:	Ab1-rho zpr-1
Fish:	WT dync1h1^mw20/mw20 fl1Tg dync1h1^mw20/mw20; fl1Tg
Anatomical Terms:	retinal cone cell retinal rod cell
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dync1h1^mw20/mw20 dync1h1^mw20/mw20; fl1Tg
Observed In:	embryonic retina morphogenesis in camera-type eye photoreceptor cell morphogenesis retina retinal cone cell retinal rod cell
Stage Range:	Day 4 to Day 5

Phenotype Detail

Acknowledgments

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