FIGURE

Fig. 7

ID

ZDB-FIG-090817-15

Publication

McMahon et al., 2009 - Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Migration of lmx1b.1:GFP-positive cells is altered following knock-down of Lmx1b. Bright field and fluorescence images of (panels A–C) control MO and (panels D–F) lmx1bdMO embryos from the Tg(- 5 kb lmx1b.1:GFP)^mw11 line. For each image developmental time is indicated at the top, anterior is to the left, and dorsal is up. Arrows indicate the location of the optic stalk region. (D) Note the significant reduction of GFP fluorescence in Lmx1b-deficient cells associated with the optic stalk. Each fluorescent image is a compressed z-stack, which includes the entire globe of the eye and optic stalk region. Images shown are from representative embryos (n = 12 total embryos tracked over time from 2 experiments).

Expression Data

Gene:	GFP
Fish:	mw11Tg mw11Tg + MO2-lmx1bb + MO3-lmx1ba
Knockdown Reagents:	MO2-lmx1bb MO3-lmx1ba
Anatomical Terms:	eye optic stalk
Stage Range:	26+ somites to Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mw11Tg + MO2-lmx1bb + MO3-lmx1ba
Knockdown Reagents:	MO2-lmx1bb MO3-lmx1ba
Observed In:	cell migration eye morphogenesis
Stage Range:	26+ somites to Pec-fin

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 332(2), McMahon, C., Gestri, G., Wilson, S.W., and Link, B.A., Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish, 287-298, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.