FIGURE

Fig. 8

ID

ZDB-FIG-090408-41

Publication

Málaga-Trillo et al., 2009 - Regulation of Embryonic Cell Adhesion by the Prion Protein

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Fig. 8

PrP-1 Regulation of Adherens, but Not Tight Junctions, in EVL Cells

Differences in the subcellular distribution of various cell junction components between control and PrP-1 morphant embryos (MO) were evaluated in the polarized epithelial cells of the EVL at the shield stage (6 hpf). In control embryos, a marked membrane localization pattern can be seen for adherens junction (E-cadherin [E-cad], β-catenin [β-cat], and F-actin) (A–C) and tight junction markers (Occludin and ZO-1) (D and E). PrP-1 knockdown induces partial mislocalization of adherens junction components (F–H) but does not affect the distribution of classical tight junction markers (I and J). Scale bars indicate 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-prnpb
Knockdown Reagent:	MO1-prnpb
Observed In:	adherens junction maintenance EVL adherens junction
Stage:	Shield

Phenotype Detail

Acknowledgments

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