FIGURE

Fig. 7

ID

ZDB-FIG-090408-40

Publication

Málaga-Trillo et al., 2009 - Regulation of Embryonic Cell Adhesion by the Prion Protein

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Fig. 7

Radial Intercalation in Control and PrP-1 Morphant Embryos

Cell movements in lateral regions of the epiblast (8 hpf) were imaged over 20 min using Nomarski optics. (Time in minutes and seconds is shown in the lower-right corner of each panel.) Selected frames from time-lapse video recordings were pseudocolored: intercalating and surrounding cells are shown in blue and green, respectively (after Kane et al. [22]), and cells forming new contacts are shown in red.

(A) In control embryos, cells from the interior layer (blue) intercalate among cells in the exterior layer (green) and establish additional cell contacts with other cells (red).

(B) In PrP-1 morphant embryos, cells from the interior layer often intercalate and then deintercalate, thereby failing to maintain attachment to cells from the exterior layer (green cells 2 and 4, and red cells).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-prnpb
Knockdown Reagent:	MO1-prnpb
Observed In:	mediolateral intercalation
Stage:	75%-epiboly

Phenotype Detail

Acknowledgments

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