FIGURE

Fig. 2

ID

ZDB-FIG-090320-72

Publication

Jing et al., 2009 - Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor

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Fig. 2

unplugged Restricts Navigating Growth Cones to a Central Muscle Zone

(A–D) Still images from time-lapse movies showing the initial migration of single CaP axons (A and B) or CaP/VaP pair axons (C and D) from the spinal cord into the myotome. Arrows point to the single wild-type CaP growth cone (A) and to the tightly fasciculated wild-type CaP/VaP growth cones (C). In contrast, unplugged CaP neurons form extensive filopodia and even multiple growth cones (arrowheads) that occupy a broader area (brackets, [B]). Similary, mutant CaP/VaP growth cones appear defasciculated and occupy a broader area compared to wild-type. Asterisks indicate interneurons also labeled by the Tg(Hb9:GFP) transgene.

Expression Data

Gene:	GFP
Fish:	ml2Tg musk^{tbr307/tbr307}; ml2Tg
Anatomical Terms:	CaP motoneuron axon CaP motoneuron growth cone CaP motoneuron neuronal cell body
Stage:	14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	musk^{tbr307/tbr307}; ml2Tg
Observed In:	CaP motoneuron growth cone motor neuron axon guidance
Stage:	14-19 somites

Phenotype Detail

Acknowledgments

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