FIGURE

Fig. S6

ID

ZDB-FIG-080508-14

Publication

Schenck et al., 2008 - The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development

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Fig. S6

Appl1 and Appl2 double knock-down
Apoptotic staining by AO (in white) on MOCK injected and Appl1/2 “low dose” double knock-down fish. 8 ng MO1A and 2 ng MO2 have been injected. Not the dramatic apoptosis in the olfactory system (asterisks), which is less pronounced in Appl1 morphants (see Figure 4). In contrast, apoptosis in the telencephalon (arrow) is of comparable level.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-appl1 + MO1-appl2
Knockdown Reagents:	MO1-appl1 MO1-appl2
Observed In:	olfactory system
Stage:	Unknown

Phenotype Detail

Acknowledgments

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Reprinted from Cell, 133(3), Schenck, A., Goto-Silva, L., Collinet, C., Rhinn, M., Giner, A., Habermann, B., Brand, M., and Zerial, M., The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development, 486-497, Copyright (2008) with permission from Elsevier. Full text @ Cell