Fig. 6
Nasal–temporal patterning of the retina in Fgf19 MO1-injected and Fgf19 mRNA-injected embryos. (a, d, f, h, k, n) Control embryos at 28 hpf. (b, e, g, i, l, o) Fgf19 MO1-injected embryos at 28 hpf. (c, j, m) Fgf19 mRNA-injected embryos at 28 hpf. (a-c) The expression of ephrin A3 was completely lost in the nasal half of the prospective retina of Fgf19 MO1-injected embryos, while the expression of ephrin A3 partially expanded into the temporal retina in Fgf19 mRNA-injected embryos. (d-g) The expression of ephrin A5a and foxg1 was severely reduced in the nasal retina of Fgf19 MO1-injected embryos. (h-j) The expression of eph A4b in the temporal half of the prospective retina partially expanded into the nasal retina in Fgf19 MO1-injected embryos, while the expression of eph A4b was decreased in the temporal retina of Fgf19 mRNA-injected embryos. (k, l) The nasal expansion of tbx5 expressetina in Fgf19 MO1-injected embryos, while the expression of eph A4b was decreased in the temporal retina of |
Genes: | |
---|---|
Fish: | |
Knockdown Reagent: | |
Anatomical Terms: | |
Stage Range: | 14-19 somites to Prim-5 |
Reprinted from Developmental Biology, 313(2), Nakayama, Y., Miyake, A., Nakagawa, Y., Mido, T., Yoshikawa, M., Konishi, M., and Itoh, N., Fgf19 is required for zebrafish lens and retina development, 752-766, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.