Gene
epha4b
- ID
- ZDB-GENE-030826-6
- Name
- eph receptor A4b
- Symbol
- epha4b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have transmembrane-ephrin receptor activity. Involved in negative regulation of axon extension; negative regulation of collateral sprouting of intact axon in response to injury; and regulation of myelination. Predicted to localize to integral component of plasma membrane; neuron projection; and receptor complex. Is expressed in several structures, including axis; immature eye; intestinal bulb primordium; nervous system; and pharyngeal arch.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Harboe et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001426 | Tyrosine-protein kinase, receptor class V, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001090 | Ephrin receptor ligand binding domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR027936 | Ephrin receptor, transmembrane domain |
| Family | IPR016257 | Ephrin receptor type-A /type-B |
| Family | IPR050449 | Ephrin receptor tyrosine kinases |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Length | Ephrin receptor ligand binding domain | Ephrin receptor, transmembrane domain | Ephrin receptor type-A /type-B | Ephrin receptor tyrosine kinases | Fibronectin type III | Fibronectin type III superfamily | Galactose-binding-like domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class V, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90ZN9
|
976 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
epha4b-201
(1)
|
Ensembl | 3,311 nt |
Interactions and Pathways
No data available
Plasmids
No data available