FIGURE

Fig. 3

ID

ZDB-FIG-080104-8

Publication

Shang et al., 2007 - The circadian system is a target and modulator of prenatal cocaine effects

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Fig. 3

Nighttime low- or high-dose cocaine exposure fails to alter the expression of zDAT, zBmal1, zGH and melatonin receptor genes during zebrafish development but continues to affect zPer3, and this effect is counteracted by melatonin. (A–E) Melatonin (100 nM for 45 min), Low (0.3 μM) or High (30 μM) cocaine doses (15 min), with or without melatonin pre-treatment (100 nM, 30 min) administered to 36-hpf embryos. N=3–4 samples/treatment group, 25 embryos per sample. Mean±SEM, t-test (vs. control), * p<0.05, ** p<0.01, *** p<0.001; One way ANOVA (between treatments), a: p<0.05, vs. cocaine-only group. Mlt-melatonin; Coc-cocaine.

Expression Data

Genes:	bmal1a gh1 mtnr1aa per3 slc6a3
Fish:	AB
Conditions:	chemical treatment: cocaine chemical treatment: melatonin chemical treatment: melatonin chemical treatment: cocaine
Anatomical Term:	whole organism
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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