FIGURE

Fig. 4

ID

ZDB-FIG-070921-7

Publication

Nambiar et al., 2007 - Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration

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Fig. 4

Regulators of the Wnt/PCP pathway are able to partially rescue col mutants. ΔNdsh (dsh; B and F) and rok2 (C and E) were able to abolish the short body axis (B and C) and short wide notochords (E and F) observed in col mutants at 3 dpf (A and D). However, canonical Wnt signaling regulated defects in col mutants still remain in injected embryos. dlx2 expression in the telencephalon (asterisk) remains reduced compared to wildtype (G) in rock2 injected col mutant embryos (I) as compared to uninjected col mutants (H). The persistence of this phenotype is also observed in ΔNdsh injected col mutants (not shown).

Expression Data

Gene:	dlx2a
Fish:	WT hdac1^b382/b382
Anatomical Term:	telencephalon
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 124(9-10), Nambiar, R.M., Ignatius, M.S., and Henion, P.D., Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration, 682-698, Copyright (2007) with permission from Elsevier. Full text @ Mech. Dev.