FIGURE

Fig. 7

ID

ZDB-FIG-070921-10

Publication

Nambiar et al., 2007 - Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration

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Fig. 7

hdac1 morphants phenocopy col mutants and hdac1 RNA rescues col mutant phenotypes. hdac1 MO (hdac MO) injected wildtype embryos at 3 dpf (B) resemble uninjected col mutants (A). Reduced dlx2 expression (asterisk) and ectopically positioned facial hindbrain motor neurons (black arrowheads) in col mutants (D and G) are phenocopied in hdac1 morphants (E and H). The position of nV neurons in r2 are marked with arrows (G–I). hdac1 RNA (hdac RNA) is able to rescue axis extension and melanophore defects in col mutants (C). Telencephalon dlx2 expression and migration of facial hindbrain motorneurons is restored in col mutants injected with hdac1 RNA (F and I compared to D and G).

Expression Data

Genes:	dlx2a isl1a
Fish:	WT hdac1^b382/b382 WT + MO1-hdac1
Knockdown Reagent:	MO1-hdac1
Anatomical Terms:	rhombomere 2 rhombomere 4 telencephalon unspecified
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hdac1^b382/b382 WT + MO1-hdac1
Knockdown Reagent:	MO1-hdac1
Observed In:	facial nerve motor nucleus melanocyte motor neuron neuron migration pectoral fin trunk
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 124(9-10), Nambiar, R.M., Ignatius, M.S., and Henion, P.D., Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration, 682-698, Copyright (2007) with permission from Elsevier. Full text @ Mech. Dev.