FIGURE

Fig. 1

ID

ZDB-FIG-070921-4

Publication

Nambiar et al., 2007 - Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration

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Fig. 1

col mutant embryos display a late axial extension phenotype. Live col mutants at 4 dpf (B) have wider notochords (n) than their wildtype siblings (A). Larger notochord diameter is observed in cross-sections of the trunk of 2 col mutants stained with antibody f59 (D) as compared to wildtype (C). col mutants also display rounded somite morphology (B) unlike chevron-shaped wildtype somites (A). In contrast, col mutants do not display prominent early CE defects. For example, ntl expression in the notochord anlage at late gastrulation of col embryos (F) is indistinguishable from wildtype embryos (E). The degree of convergence of the neural plate border at the 12-somite stage identified by foxd3 expression also appears normal in col mutants (G and H).

Expression Data

Genes:	foxd3 tbxta
Fish:	WT hdac1^b382/b382
Anatomical Terms:	axial chorda mesoderm neural keel
Stage Range:	90%-epiboly to 10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hdac1^b382/b382
Observed In:	notochord somite
Stage Range:	Prim-5 to Day 4

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 124(9-10), Nambiar, R.M., Ignatius, M.S., and Henion, P.D., Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration, 682-698, Copyright (2007) with permission from Elsevier. Full text @ Mech. Dev.