FIGURE

Fig. 1

ID

ZDB-FIG-070822-28

Publication

Yang et al., 2007 - Mutations in gfpt1 and skiv2l2 Cause Distinct Stage-Specific Defects in Larval Melanocyte Regeneration in Zebrafish

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Fig. 1

Mutations Specific to Melanocyte Regeneration (A–F) eartha^j23e1 (C) and julie^j24e1 mutants (E) both develop larval melanocyte patterns nearly identical to wild-type larvae (A), although melanocytes in eartha^j23e1 mutants appear to have lighter pigmentation than that in the wild-type larvae. Upon larval melanocyte ablation by MoTP (14–72 hpf), wild-type larvae (B) regenerate many melanocytes at 5 dpf (arrowhead in [B]), while eartha^j23e1 (arrowhead in [D]) and julie^j24e1 (arrowhead in [F]) mutants largely fail to regenerate melanocytes. Additional phenotypes are indicated by an arrow in (C) marking a shortened pharyngeal skeleton in eartha^j23e1 mutants and by an arrow in (E) indicating small eyes and head in julie^j24e1 mutants. (G–H) The numbers of melanocytes in the untreated (G) and MoTP-treated (H) wild-type and mutant larvae at 5 dpf. Scale bar: 300 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT gfpt1^j23e1/j23e1 (SJD/C32) mtrex^j24e1/j24e1 (SJD/C32)
Condition:	chemical treatment: pharmaceutical
Observed In:	melanocyte melanocyte differentiation ventral mandibular arch
Stage:	Day 5

Phenotype Detail

Acknowledgments

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