FIGURE

Fig. 9

ID

ZDB-FIG-070802-27

Publication

Plaster et al., 2007 - REREa/Atrophin-2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 9

The proper expression of fgf3 and fgf8 and fgf target genes, sef and mkp3, requires histone deacetylase (HDAC) activity. A-H: All panels show lateral views of whole-mount in situ hybridizations of seven-somite stage WT embryos treated with dimethylsulfoxide (DMSO, A,C,E,G) or 350 nM Trichostatin A (TSA, B,D,F,H) from dome to the seven-somite stage. Probes are shown in the bottom left corner of each wild-type panel. A,B,E,F: The forebrain (arrows) and tail bud (asterisk) expression of all markers is decreased or absent in TSA-treated embryos while the midbrain-hindbrain boundary (MHB) domains (dots) are decreased and diffuse. Both fgf8 (A,B) and mkp3 (E,F) expression in the developing somites (arrowheads) is also lost in TSA-treated embryos.

Expression Data

Genes:	dusp6 fgf3 fgf8a il17rd
Fish:	WT
Condition:	chemical treatment: trichostatin A
Anatomical Terms:	forebrain neural rod midbrain hindbrain boundary neural rod presumptive telencephalon somite tail bud
Stage:	5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dev. Dyn.