FIGURE

Fig. 5

ID

ZDB-FIG-070802-23

Publication

Plaster et al., 2007 - REREa/Atrophin-2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development

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Fig. 5

rerea interacts genetically with fgf8 in posterior mesoderm development. A-C: Lateral views of live 24 hpf embryos with genotypes in the upper right corner. A′-C′: Inset panels show the corresponding lateral views of diphosphorylated ERK1&2 (pERK) immunostained tail buds at 13 somites. Arrows denote the position of pERK staining. D-I: Whole-mount in situ hybridizations of papc at 4 somites (D-F) or myod with Ntl immunostains at 16 somites (G-I) shown in dorsal view with genotypes shown in the upper right corner. The arrowhead in I marks a gap in Ntl staining. "WT(bab)" notes that there is no observable difference between wild-type (WT) and bab embryos. ace shows a slight reduction in the amount of posterior mesoderm (B) and presomitic mesoderm as seen by papc expression at four somites (E), while bab;ace (C,F) shows a severe reduction in comparison to wild-type or bab (A,D).

Expression Data

Genes:	myod1 pcdh8 tbxta
Fish:	WT fgf8a^{ti282a/ti282a} rerea^tb210/tb210 fgf8a^{ti282a/ti282a}; rerea^tb210/tb210
Anatomical Terms:	axial mesoderm paraxial mesoderm segmental plate
Stage Range:	1-4 somites to 14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgf8a^{ti282a/ti282a} rerea^tb210/tb210 fgf8a^{ti282a/ti282a}; rerea^tb210/tb210
Observed In:	post-vent region post-vent region mesoderm segmental plate
Stage Range:	1-4 somites to Prim-5

Phenotype Detail

Acknowledgments

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