FIGURE

Fig. 8

ID

ZDB-FIG-070802-26

Publication

Plaster et al., 2007 - REREa/Atrophin-2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development

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Fig. 8

Histone deacetylase (HDAC) activity is required for proper Fgf signaling during development of the posterior mesoderm. A-D: Lateral views of live 26 hours postfertilization (hpf) wild-type (A,B) or ace (C,D) embryos, treated with either dimethylsulfoxide (DMSO) control medium (A,C) or 200 nM Trichostatin A (TSA, B,D) are shown. TSA-treated embryos are slightly delayed. The black arrow in D marks severely disrupted tail mesoderm, resembling the bab;ace phenotype at 24 hpf. E-H: Whole-mount in situ hybridizations (dorsal views on the tail bud) of papc at the four-somite stage in wild-type embryos (E,F) or ace (G,H) treated with DMSO control medium (E,G) or 200 nM TSA (F,H) from 30% epiboly.

Expression Data

Gene:	pcdh8
Fish:	WT fgf8a^{ti282a/ti282a}
Condition:	chemical treatment: trichostatin A
Anatomical Term:	paraxial mesoderm
Stage:	1-4 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgf8a^{ti282a/ti282a}
Condition:	chemical treatment: trichostatin A
Observed In:	post-vent region mesoderm segmental plate
Stage Range:	1-4 somites to Prim-5

Phenotype Detail

Acknowledgments

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