FIGURE

Fig. 6

ID

ZDB-FIG-070622-2

Publication

Pauls et al., 2007 - Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts

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Fig. 6

The endocrine pancreas in nkx2.2a-morphant embryos. Ventral views. (A–C, E–G) 32 hpf. (D, H) 48 hpf. Pancreatic hormone expression in control embryos (A–D) and representative MOnk-5UTR injected embryos (E–H). (A, E) Insulin, (B, F) somatostatin, (C, G) glucagon, (D, H) ghrelin. Using ImageJ software we could calculate that insulin expression in panel E is 52% less than control (A), while glucagon expression in panel G is 43% less than control (H). In panel H, ghrelin expression levels are 60% more than control (D).

Expression Data

Genes:	gcga ghrl ins sst2
Fish:	WT WT + MO3-nkx2.2a
Knockdown Reagent:	MO3-nkx2.2a
Anatomical Terms:	pancreatic B cell pancreatic bud
Stage Range:	Prim-15 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-nkx2.2a
Knockdown Reagent:	MO3-nkx2.2a
Observed In:	endocrine pancreas
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 304(2), Pauls, S., Zecchin, E., Tiso, N., Bortolussi, M., and Argenton, F., Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts, 875-890, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.