FIGURE

Fig. 6

ID

ZDB-FIG-070621-8

Publication

Cheng et al., 2006 - The homeobox gene irx1a is required for the propagation of the neurogenic waves in the zebrafish retina

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Fig. 6

Spread of the waves of shh-GFP expression is dependent on irx1a. In vivo time-lapse recording the eyes of a live embryo carrying the shh-GFP transgene, ventral view, anterior to the top. In control embryos (A–F), shh-GFP is expressed in the ventronasal side of the control retina (A), its expression then spreads to the central retina at about 36 hpf (C), and to the entire GCL and INL at about 42 hpf (F). The expression of shh-GFP is initiated in the irx1a morphant retina (I, arrow) with a delay of about 4 hrs. In contrast to the wildtype, GFP is not expressed in the central and dorsal regions of the irx1a morphant retina (G–L). Note both the GCL and INL shh-GFP waves are blocked in irx1a morphant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sb28Tg + MO2-irx1a sb28Tg + MO3-irx1a
Knockdown Reagents:	MO2-irx1a MO3-irx1a
Observed In:	retina retina development in camera-type eye
Stage Range:	Prim-15 to High-pec

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 123(3), Cheng, C.W., Yan, C.H., Hui, C.C., Strähle, U., and Cheng, S.H., The homeobox gene irx1a is required for the propagation of the neurogenic waves in the zebrafish retina, 252-263, Copyright (2006) with permission from Elsevier. Full text @ Mech. Dev.