FIGURE

Fig. 3

ID

ZDB-FIG-070620-41

Publication

Hans et al., 2007 - Changes in retinoic acid signaling alter otic patterning

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Fig. 3

Loss and excess of RA signaling affect different tissues. (A-F) In comparison to controls (A,D) or to embryos treated with 20 nM RA (C,F), r4-specific fgf3 expression is delayed by the end of gastrulation in embryos depleted of RA signaling (DEAB, B) and remains reduced in an enlarged r4 primordium at the three-somite stage (E). (G-I) An enlarged r4-specific fgf8 expression domain is also present in embryos depleted of RA signaling (H) compared with control (G) or 20 nM RA-treated (I) embryos. (J-L) foxi1 expression is indistinguishable from control embryos (J) after RA-signaling depletion (K), whereas the application of 20 nM RA leads to ectopic expression within the entire preplacodal domain (L). (M-O) Expression of dlx3b in the preplacodal domain is unaffected by loss (N) or excess (O) of RA signaling. Dorsal views with anterior towards the top. Scale bar: 90 µm.

Expression Data

Genes:	dlx3b fgf3 fgf8a foxi1
Fish:	AB
Conditions:	chemical treatment: all-trans-retinoic acid chemical treatment by environment: 4-(diethylamino)benzaldehyde
Anatomical Terms:	hindbrain neural plate otic placode preplacodal ectoderm presumptive rhombomere 4
Stage Range:	90%-epiboly to 1-4 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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