FIGURE

Fig. 1

ID

ZDB-FIG-070620-39

Publication

Hans et al., 2007 - Changes in retinoic acid signaling alter otic patterning

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Fig. 1

Loss and excess of RA signaling generate opposite phenotypes. (A-F) Compared to control embryos, otic vesicles are reduced or increased in size, respectively, after depletion of RA signaling (DEAB) or after the application of 10 nM RA, as assessed both by morphology at 50 hpf (A-C) or stm expression at 22 hpf (D-F). (G-L) Reduction or increase in the number of preotic cells is already evident at placodal (G-I, 12-somite stage) and preplacodal (J-L, 5-somite stage) stages after labeling with cldna (G-I) or pax8 (J-L). (A-C) Lateral views of live otic vesicles with anterior to the left and dorsal towards the top. (D-L) Dorsal views with anterior towards the top. Scale bar: 35 µm.

Expression Data

Genes:	cldna pax8 stm
Fish:	AB
Conditions:	chemical treatment: all-trans-retinoic acid chemical treatment by environment: 4-(diethylamino)benzaldehyde
Anatomical Terms:	non neural ectoderm otic placode otic vesicle
Stage Range:	5-9 somites to 26+ somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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