FIGURE

Fig. 3

ID

ZDB-FIG-070219-12

Publication

Hernandez et al., 2007 - Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

A selective antagonist of Cyp26 enzymes recapitulates the cyp26a1 ; cyp26b1;cyp26c1 phenotype. RNA in situ hybridizations with the markers described in Fig. 2. (A-F) Compared with DMSOtreated controls (A,C,E), treatment with 10 μM R115866 (B,D,F) causes an anterior shift of hoxb1a (arrowhead in A,B) and hoxd4 (arrowhead in C,D) towards the presumptive cerebellum, marked by en3 (red in A,B) and by pax2a (brackets in C-F). This effect of R115866 is reversed by co-treatment with 10 μM DEAB (E,F). Scale bars: 100 μm. Scale bar in A is for A,B; Scale bar in C is for C-F.

Expression Data

Genes:	egr2b en2b hoxb1a hoxd4a pax2a
Fish:	WT
Conditions:	chemical treatment: talarozole chemical treatment: 4-(diethylamino)benzaldehyde chemical treatment: 4-(diethylamino)benzaldehyde
Anatomical Terms:	midbrain midbrain hindbrain boundary optic stalk otic placode otic vesicle rhombic lip rhombomere 3 rhombomere 5 rhombomere 7 rhombomere 8 unspecified
Stage:	14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development