FIGURE

Fig. 5

ID
ZDB-FIG-060602-1
Publication
Davidson et al., 2006 - The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis
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Fig. 5

 Rescue of gata1 and runx1a Expression in cdx-deficient Embryos. (A) Whole mount in situ hybridizations showing gata1 transcripts (purple) in wild-type, doubly deficient (cdx1amo;cdx4−/−), hoxb7a-injected, and hoxa9a-injected doubly deficient embryos at the 18-somite stage (flatmounted embryos shown in dorsal views of the trunk with anterior to the left). (B) Expression of runx1a, fli1a, and rag1 in cdx-deficient embryos (lateral views, anterior to the left). Arrows in the runx1a-stained embryos at 36 hpf indicate the extent of artery expression, and higher magnification views of the posterior trunk are shown alongside. A similar region in fli1a-stained embryos is shown with short arrows indicating the dorsal aorta and axial vein. Transcripts for rag1 in the thymus of 4 dpf embryos are indicated by arrowheads. (C) Expression of runx1a in wild-type, cdx4−/− mutants, and hoxa9a-injected cdx4−/− embryos at 48 hpf. Arrows indicate the extent of runx1a staining in the dorsal aorta. Asterisks mark runx1a+ cranial motorneurons in the hindbrain, and the arrowhead in the hoxa9a-rescued embryo indicates the short yolk tube extension.

Expression Data
Genes:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage Range: 14-19 somites to Day 4

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 292(2), Davidson, A.J., and Zon, L.I., The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis, 506-518, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.