FIGURE

Fig. 4

ID

ZDB-FIG-050228-9

Publication

Norton et al., 2005 - Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Floorplate develops in mol^-/- embryos independently of Hh activity. Lateral views (A,B), dorsal views (C-H) and transverse sections (I-R) of wild-type (A,C,E,G,I,K,M,O,Q) and mol^-/- (B,D,F,H,J,L,N,P,R) embryos with (A,B,D,G,H) and without (C,E,F,I-R) cyclopamine treatment. (A,B) Both the wild-type and the mol^-/- embryo treated with cyclopamine have cuboidally shaped floorplate cells (arrowhead) at 20 hpf. (C,D) Clutches of embryos from parents heterozygous for the mol^tv53a mutation. Treatment with cyclopamine between the 4-hour and 2-somite stages did not appear to affect expression of twhh in either wild-type or mol^-/- mutants. (E-H) Wild-type and mol^-/- embryos showing patchy ntn1 expression after treatment with cyclopamine. (I-R) Transverse sections through the spinal cord of wild-type and mol^-/- embryos showing changes in floorplate expression of various genes in the mutants. cpm, cyclopamine.

Expression Data

Genes:	foxa nkx2.2a nkx2.2b ntn1b shhb
Fish:	WT foxa2^tv53a/tv53a
Condition:	chemical treatment: Cyclopamine
Anatomical Terms:	floor plate neural plate
Stage Range:	1-4 somites to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development