ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Spatial expression of casp1 and casp19a at 24, 48, 72 and 96 hpf.

Lateral (A-D) and dorsal (E-H) views of whole embryos stained for casp1 by ISH show expression in the pharyngeal arches (pa) at 48, 72 and 96 hpf and in the intestinal bulb (ib) at 72 and 96 hpf. Casp19a expression is strongly detected in the pharyngeal arches (pa) at 48, 72 and 96 hpf, and is also seen in the epidermis (ep) at 48 and 72 hpf (lateral views in J and K, dorsal views in N and O). Expression is also observed in the proctodeum (pr) and at lower levels in the muscles pioneers (mp) at 48 hpf. Scale bar: 200 μm.

Spatial expression of casp2 and casp9 at 24, 48, 72 and 96 hpf.

Lateral views of whole embryos stained for casp2 (A-D) and casp9 (E-H) by ISH. Casp2 is expressed in the midbrain (mb) and hindbrain (hb) at all stages analyzed. Expression is also observed in the pharyngeal arches (pa) and retina (r) at 48, 72 and 96 hpf (B-D), and in the intestinal bulb (ib) at 72 and 96 hpf (C, D). Casp2 becomes strongly detected in the liver (lv) at 96 hpf (D). Casp9 is expressed at high levels in the olfactory placodes (op) and at lower levels in the gut (g) and proctodeum (pr) at 24 hpf (E). Casp9 appears ubiquitously expressed at low levels at 48 and 72 hpf and is strongly detected in the retina, diencephalon (di), midbrain, hindbrain and gut from 48 to 96 hpf (F-H). Scale bar: 200 μm.

Spatial expression of the caspase-8 family members casp8a, casp10 and casp20 at 24, 48, 72 and 96 hpf.

Lateral views of whole embryos stained for casp8a (A-D), casp10 (E-H) and casp20 (I-L) by ISH. Casp8a is expressed in the hindbrain (hb), muscles (ms) and at the floorplate (fp) at 24 hpf (A). Its expression is then strongly detected in the retina (r), diencephalon (di), midbrain (mb), hindbrain and muscles (ms) at 48 hpf (B). Additional expression in the intestinal bulb (ib) is observed at 72 and 96 hpf (C, D). Casp10 expression is detected at the floorplate at 24 and 48 hpf (E, F) and in the pharyngeal arches (pa) at 48 hpf (F). A strong expression is detected in the pharyngeal arches, muscles and intestinal bulb at 72 hpf (G). Casp10 remains highly detected in the pharyngeal arches and intestinal bulb at 96 hpf (H). Casp20 is strongly expressed in the nervous system (ns), vascular system (vs), proctodeum (pr) and throughout the gut (g) at 24 hpf (I). Its expression becomes restricted to the pharyngeal arches and the intestinal bulb at 48, 72 and 96 hpf (J-L). Scale bar: 200 μm.

Spatial expression of the executioner caspases casp3a, casp3b, casp6a, casp7 and casp21 at 24, 48, 72 and 96 hpf.

Lateral views of whole embryos stained for casp3a (A-D), casp3b (E-H), casp6a (I-L), casp7 (M-P), and casp21 (Q-T) by ISH. Casp3a is expressed in the olfactory placodes (op), diencephalon (di), midbrain (mb) and hindbrain (hb) at 24 hpf (A). Expression remains high in the nervous system at 48, 72 and 96 hpf and is strongly detected in the olfactory bulb (ob), retina (r), and optic tectum (ot) (B-D). Casp3a becomes strongly expressed in the intestinal bulb and liver at 96 hpf (D). Casp3b expression is not detected at 24 hpf (E) but becomes visible at 48 and 72 hpf, notably in the pharyngeal arches (pa), muscles (ms) and intestinal bulb (ib) (F, G). Expression becomes restricted to the pharyngeal arches and intestinal bulb at 96 hpf (H). Casp6a expression is mostly detected in the lens (ln), gut (g) proctodeum (pr) and epidermis (ep) at 24 hpf (I). It becomes restricted to the pharyngeal arches at 48 hpf (J), and is strongly detected in the pharyngeal arches, intestinal bulb and liver (lv) at 72 and 96 hpf (K, L). Casp7 expression appears restricted to the lens at 48 and 72 hpf (N, O). It expands to the intestinal bulb at 96 hpf (P). Casp21 expression is not visible at 24 hpf (Q) but is detected in the primary head sinus (phs) at 48 hpf (R). It is maintained in the primary head sinus and is also observed in the primordial hindbrain channel (phbc) and the muscles at 72 hpf (S). Casp21 expression becomes visible in the nervous system, pharyngeal arches and intestinal bulb at 96 hpf (T). Scale bar: 200 μm.

Spatial expression of casp17 at 24, 48, 72 and 96 hpf.

Lateral (A-D) and dorsal (E-H) views of a whole embryo stained for casp17 by ISH show a strong and specific expression of casp17 in the liver (lv) and intestinal bulb (ib) at 96 hpf (D, H). Scale bar: 200 μm.

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.