Gene

casp3a

ID

ZDB-GENE-011210-1

Name

caspase 3, apoptosis-related cysteine peptidase a

Symbol

casp3a Nomenclature History

Previous Names

casp3
zgc:100890

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Exhibits peptidase activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of apoptotic process; and regulation of collateral sprouting in absence of injury. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; and lung non-small cell carcinoma. Is expressed in several structures, including axis; germ ring; gonad; gut; and nervous system. Orthologous to human CASP3 (caspase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

66 figures from 50 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu109 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With casp3a Human Ortholog

No data available

Associated With casp3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016129	Peptidase family C14A, His active site
Active_site	IPR033139	Peptidase family C14A, cysteine active site
Domain	IPR001309	Peptidase C14, p20 domain
Domain	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
Domain	IPR011600	Peptidase C14, caspase domain
Domain	IPR015917	Peptidase C14A, caspase catalytic domain
Homologous_superfamily	IPR029030	Caspase-like domain superfamily

Domain Details Per Protein

Protein	Length	Caspase-like domain superfamily	Peptidase C14A, caspase catalytic domain	Peptidase C14, caspase domain	Peptidase C14, caspase non-catalytic subunit p10	Peptidase C14, p20 domain	Peptidase family C14A, cysteine active site	Peptidase family C14A, His active site
UniProtKB:A0A2R8QUC0 InterPro PDB	282
UniProtKB:Q98UI8 InterPro PDB	282

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	casp3a-201 (1) Ensembl	Ensembl	2,918 nt	Select Tool
mRNA	casp3a-202 (1) Ensembl	Ensembl	862 nt	Select Tool
mRNA	casp3a-203 (1) Ensembl	Ensembl	792 nt	Select Tool
mRNA	casp3a-204 (1) Ensembl	Ensembl	471 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations