ZFIN Image: van der Velden et al., 2012, Fig. 1

Image

Figure Caption

Fig. 1 Generation of ring1b mutants. (A) Schematic representation of the zebrafish ring1b gene depicting the location of the ZFN target site. (B) Wild-type ring1b sequence is shown at the top; the ZFN target sites are highlighted in yellow. ZFN-induced bp insertions are highlighted in red, and deletions in gray. (C,C′) ring1b mRNA staining in brain and pectoral fins in wild-type larvae. (D,D′) Expression is absent in ring1b mutants. (E,F) Ring1b (E) and mono-ubiquitylated histone H2A (F) are not detected in 72 hpf ring1b mutants by western blot analysis. (G,H) Dorsal view of wild-type (G) and ring1b (H) larvae at 72 hpf. Asterisks indicate the lack of pectoral fins in ring1b mutants.

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Acknowledgments

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