ZFIN Image: Aman et al., 2008, Fig. 5

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Figure Caption

Fig. 5 Fgf Signaling Inhibits Wnt/β-Catenin Signaling via Induction of dkk1

(A and B) SU5402 treatment leads to ectopic induction of the Wnt/β-catenin signaling targets lef1 and axin2 in 36 hpf embryos.

(C) In WT embryos, dkk1 is expressed adjacent to the unpatterned tip of the primordium.

(D–F) (D) dkk1 is a Fgf target, as it is highly upregulated in apc^mcr mutant primordia and is absent in (E) Fgf signaling-depleted WT, as well as in (F) Fgf signaling-depleted apc^mcr mutant primordia.

(G and H) Morpholino knockdown of dkk1 causes expansion of lef1 and axin2, similar to loss of Fgf signaling. The scale bar is equal to 40 μM.

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Acknowledgments

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Reprinted from Developmental Cell, 15(5), Aman, A., and Piotrowski, T., Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression, 749-761, Copyright (2008) with permission from Elsevier. Full text @ Dev. Cell