ZFIN Image: Alt et al., 2006, Fig. 1

Image

Figure Caption

Fig. 1 Differentiation markers start to be expressed in the thyroid primordium during embryonic development in zebrafish. A: Simplified sketch depicting the physiological activity of a vertebrate thyroid follicle cell (blue, nucleus light blue). The red arrow indicates that Ctsb is also required for human thyroglobulin (TG) degradation after endocytosis. Note that the gene slc5a5 encodes the sodium/iodide symporter NIS. For further details, see text. B-K: Expression of thyroid markers in zebrafish embryos. Whole-mounts (B-G) and sections (H-K); lateral views (B,C,F,G) and ventral views (D,E), anterior always to the left. The stage is shown bottom right, the probe/staining bottom left. B-I: Wild-type embryos; J,K: cross-sections of noi^tu29 homozygous embryos. Arrows point to the thyroid primordium, asterisks mark pharyngeal mesenchyme, and arrowheads expression of ctsb in the yolk syncytial layer. hy, hypothalamus; J^-, iodide; TPO, thyroperoxidase.

Figure Data

Expression / Labeling details

Acknowledgments

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