Gene

ctsba

ID

ZDB-GENE-040426-2650

Name

cathepsin Ba

Symbol

ctsba Nomenclature History

Previous Names

ctsb
id:ibd1201
wu:fa13g05
wu:fb34e12
zgc:55862
zgc:65809
zgc:77181 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have cysteine-type endopeptidase activity. Involved in dorsal/ventral pattern formation; fin regeneration; and morphogenesis of an epithelium. Predicted to localize to extracellular space and lysosome. Human ortholog(s) of this gene implicated in diabetes mellitus. Is expressed in several structures, including blastoderm cell; endocrine system; macrophage; midbrain hindbrain boundary; and yolk. Orthologous to human CTSB (cathepsin B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:65809 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from Langdon et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctsba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Keratolytic winter erythema	148370

Associated With ctsba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR000169	Cysteine peptidase, cysteine active site
Active_site	IPR025660	Cysteine peptidase, histidine active site
Active_site	IPR025661	Cysteine peptidase, asparagine active site
Domain	IPR000668	Peptidase C1A, papain C-terminal
Domain	IPR012599	Peptidase C1A, propeptide
Family	IPR013128	Peptidase C1A
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily

Domain Details Per Protein

Protein	Length	Cysteine peptidase, asparagine active site	Cysteine peptidase, cysteine active site	Cysteine peptidase, histidine active site	Papain-like cysteine peptidase superfamily	Peptidase C1A	Peptidase C1A, papain C-terminal	Peptidase C1A, propeptide
UniProtKB:Q6PH75 InterPro	330

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ctsba-201 (1) Ensembl	Ensembl	1,429 nt	Select Tool ZFIN BLAST
mRNA	ctsba-208 (1) Ensembl	Ensembl	920 nt	Select Tool ZFIN BLAST
ncRNA	ctsba-002 (1) Ensembl	Ensembl	777 nt	Select Tool ZFIN BLAST
ncRNA	ctsba-003 (1) Ensembl	Ensembl	939 nt	Select Tool ZFIN BLAST
ncRNA	ctsba-004 (1) Ensembl	Ensembl	778 nt	Select Tool ZFIN BLAST
ncRNA	ctsba-005 (1) Ensembl	Ensembl	796 nt	Select Tool ZFIN BLAST
ncRNA	ctsba-007 (1) Ensembl	Ensembl	562 nt	Select Tool ZFIN BLAST
ncRNA	ctsba-008 (1) Ensembl	Ensembl	619 nt	Select Tool ZFIN BLAST
ncRNA	ctsba-009 (1) Ensembl	Ensembl	848 nt	Select Tool ZFIN BLAST
ncRNA	ctsba-010 (1) Ensembl	Ensembl	563 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations