Gene
gars1
- ID
- ZDB-GENE-030131-9174
- Name
- glycyl-tRNA synthetase 1
- Symbol
- gars1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have glycine-tRNA ligase activity. Involved in translation. Predicted to localize to mitochondrion. Used to study Charcot-Marie-Tooth disease type 2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and distal hereditary motor neuronopathy type 5A. Is expressed in several structures, including anterior neural keel; blood island; central nervous system; heart; and segmental plate. Orthologous to human GARS1 (glycyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144596 (11 images)
- IMAGE:7162501 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant distal hereditary motor neuronopathy 5 | Alliance | Neuronopathy, distal hereditary motor, autosomal dominant 5 | 600794 |
| Charcot-Marie-Tooth disease type 2D | Alliance | Charcot-Marie-Tooth disease, type 2D | 601472 |
| Spinal muscular atrophy, infantile, James type | 619042 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 2 | gars1s266/s266 | standard conditions | Malissovas et al., 2016 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Interactions and Pathways
No data available
Plasmids
No data available