FIGURE

Fig. 3

ID

ZDB-FIG-241104-24

Publication

L�gar� et al., 2024 - CHCHD10^P80L knock-in zebrafish display a mild ALS-like phenotype

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Fig. 3

Homozygous chchd10P83L/P83L display reduced motor function and reduced survival compared to wild type larvae. A, Representative individual traces of motor activity of zebrafish larvae aged 5 dpf. B, Quantification of free swim mean velocity: chchd10P83L/P83L = 3.26 mm/s, wild type = 5.16 mm/s (Mann-Whitney, U = 118, p < 0.0001). Sample size (n) are as follows: chchd10P83L/P83L = 36, wild type = 20. Data represented as single data points and mean � S.E.M. C, Larval chchd10P83L/P83L displayed reduced survival when compared to wild type zebrafish (Log-rank test, Mantel-Cox: ?2 = 7.97, p < 0.01). Sample size (n) are as follows: chchd10 P83L/P83L = 90, wild type = 40.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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