Phenotypes found in esr1 mutants. A) Lateral view of a WT sibling, illustrating the measure of the standard length (orange arrow) and graphs representing the measures of standard lengths (relative to the mean of the WT larvae) of each mutant compared to their WT siblings; B) Dorsal view of the stained head cartilage of a 5 dpf WT larva; C) Observed chondrocranium malformations in esr1 mutant fish: total absence of ceratobranchial 1–5 (green arrows), reduced Meckel's cartilage (orange arrow), thinner palatoquadrate (black arrow) and deformed ceratohyals (violet arrow; D) another example of observed malformations in 5 dpf zebrafish larvae: heavily reduced or total absence of Meckel's cartilage (orange arrow), deformed ethmoid plate (red arrow), thinner palatoquadrate (black arrow), heavily deformed ceratohyal (violet arrow) and absence of ceratobranchials 1–5 (green arrow). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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