FIGURE

Fig. 5

ID

ZDB-FIG-240829-94

Publication

Confino et al., 2024 - A deleterious variant of INTS1 leads to disrupted sleep-wake cycles

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Fig. 5

Ints1-deficient zebrafish larvae exhibit increased dbh mRNA expression in the locus coeruleus but not in the medulla oblongata. (A) Representative image, showing of dbh mRNA expression by whole-mount in situ hybridization of 5 dpf Ints1-deficient (right) and WT sibling (left) larvae (dorsal views). The locus coeruleus is encircled (green). (B) Quantification of the dbh mRNA signal in the locus coeruleus reveals significantly elevated expression in Ints1-deficient (−/−) larvae compared with their WT siblings (**P<0.01, two-tailed t-test assuming equal variance; n=7). (C) Quantification of dbh mRNA levels in the medulla oblongata shows no difference between Ints1-deficient larvae and their WT siblings (n=7). Error bars in B and C represent ±s.e.

Expression Data

Gene:	dbh
Fish:	WT ints1^tlv13/tlv13 ints1^tlv14/tlv14
Anatomical Terms:	locus coeruleus medulla oblongata
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ints1^tlv13/tlv13 ints1^tlv14/tlv14
Observed In:	locus coeruleus
Stage:	Day 5

Phenotype Detail

Acknowledgments

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