FIGURE

Fig. 3

ID

ZDB-FIG-240829-55

Publication

Yu et al., 2024 - The embryonic zebrafish brain is exclusively colonized by pu.1-dependent and lymphatic-independent population of microglia

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Fig. 3

Microglia originated from macrophages instead of lyve1b+ lymphatic vessels. (A) Schematic view of lineage tracing workflow. (B) Fluorescent images show the labeling efficiency of GFP+ microglia in the brain of 5-dpf Tg(lyve1b:CreER;mpeg1:loxP-DsRedx-loxP-eGFP) and Tg(mfap4:CreER;mpeg1:loxP-DsRedx-loxP-eGFP) larvae treated with 4-hydroxytamoxifen (4-OHT) from 22 hpf to 5 dpf. (C) Fluorescent images show the labeling efficiency of GFP+ blood vessels in the brain of 5-dpf Tg(lyve1b:CreER;kdrl:loxP-DsRedx-loxP-eGFP) and Tg(mfap4:CreER;kdrl:loxP-DsRedx-loxP-eGFP) larvae treated with 4-OHT from 22 hpf to 5 dpf.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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