FIGURE

Fig. 11

ID

ZDB-FIG-240703-125

Publication

Chi et al., 2024 - Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation

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Fig. 11

The prospective pathomechanism contributing to the FD-induced hepatic lipid accumulation. FD prevents mTOR phosphorylation, which enhances autophagic initiation. The decreased mTOR phosphorylation also down-regulates cathepsin L expression, which results in ineffective lysosomal activity and impaired autolysosome maturation, leading to disrupted autophagic flux and hepatic lipid accumulation

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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