FIGURE

Fig. 1

ID

ZDB-FIG-240618-56

Publication

Sobah et al., 2024 - Stat3 regulates developmental hematopoiesis and impacts myeloid cell function via canonical and non-canonical modalities

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Fig. 1

Generation of zebrafish Stat3 mutants. Schematic of the STAT3 protein outlining the various functional domains: N-terminal, CCD (coiled-coil domain), DBD (DNA binding domain), linker, SH2 (Src homology 2 domain), and TAD (transactivation domain), along with relevant sections of the zebrafish stat3 gene showing introns (black lines) and exons (colored boxes) encoding the indicated protein domains as well its targeting by sgRNAs (a). Sequence traces of representative homozygous wild-type (WT, stat3wt/wt) and knockout (KO, stat3ko/ko) (b) and WT and transactivation domain truncation (ΔTAD, stat3Δtad/Δtad) (c) mutant fish, with nucleotides and corresponding amino acids shown. In each case, nucleotide sequences deleted are boxed in purple with de novo amino acids in red. Schematic of Stat3 proteins expressed in WT, KO, and ΔTAD fish (d).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Innate Immun.