FIGURE

Fig. 4

ID

ZDB-FIG-240323-4

Publication

Ma et al., 2024 - METTL3-dependent m⁶A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway

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Fig. 4

PSEN1 is modulated by METTL3-mediated m⁶A RNA methylation.

A The protein level of PSEN1 in BMSCs, HEPM cells and DPSCs with METTL3-knockdown and control groups. B The relative expression of PSEN1 detected at the RNA level after treatment with DAA in at various concentrations (0 μmol, 600 μmol and 700 μmol). C, D Potential m⁶A sites in full-length PSEN1 gene predicted using SRAMP. E The wild-type or mutant m⁶A consensus sequence fused with the firefly luciferase reporter. F–H The transcription levels of wild-type and mutant PSEN1 in BMSCs, HEPM cells and DPSCs. I–K The m⁶A methylation level of the PSEN1 at specific modification site (m⁶A1585) and control site (A1579) using SELECT in control and METTL3 knockdown cells. Results were presented as mean ± SD of three independent experiments. *P < 0.05, **P < 0.01 or ***P < 0.001 indicates a significant difference between the groups.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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