FIGURE

Fig. 5.

ID

ZDB-FIG-230916-7

Publication

Kim et al., 2023 - Intrinsic and extrinsic regulation of rhabdomyolysis susceptibility by Tango2

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Fig. 5.

Exercise-induced skeletal muscle damage in Tango2 deficiency. (A) Whole-mount (green) phalloidin staining of control and tango2 mutants (tango2^bwg210 and tango2^bwg211) in the presence or absence of methylcellulose (MC) treatment. tango2 mutants exhibited extensive overstretched sarcomeres (arrows) and damaged myofibers (arrowheads) on swimming in the MC-containing water compared to those in controls (n=6-8 in each group). Nuclei are shown in blue. Images are representative of n=6 larvae in each group. Scale bar: 5 µm. (B,C) Quantification of the swimming behavior of control and tango2 mutants (tango2^bwg210 and tango2^bwg211) before and after MC treatment (n=96). Two-way ANOVA (mixed model) with multiple comparisons was performed between different groups. ns, not significant; *P<0.05; **P<0.01; ***P<0.005.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT tango2^{bwg210/bwg210} tango2^{bwg211/bwg211}
Condition:	chemical treatment by environment: methyl cellulose
Observed In:	skeletal muscle cell swimming behavior
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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