FIGURE

Fig. 3

ID

ZDB-FIG-230916-290

Publication

Elsaid et al., 2023 - Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla^-/- zebrafish model of Fabry disease

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Fig. 3

Mitochondrial cristae morphology and area determination in proximal and distal tubules performed using TEM images and total antioxidant determination (TAC) in wild-type and GLA-mutant Zebrafish. A, B Individual score grades across the whole mitochondrial population analyzed in cells from renal proximal and distal tubules; C, D Total cristae area in cells from proximal and distal tubules; E, F Cristae volume in proximal and distal renal tubules; G, H Cumulative cristae mean scores for proximal and distal renal tubules, I TAC levels in adult (9-months-old) zebrafish kidney tissue lysates. For mitochondria cristae morphology quantification data represented as mean with upper 95% confidence interval. For TAC values are represented as violin plot representing the median and IQ ranges. Data were analyzed using Mann–Whitney test; ****p-value ≤ 0.00001; **p-value ≤ 0.001

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gla^huh1/huh1 (AB/TU)
Observed In:	distal early tubule mitochondrial crista kidney antioxidant proximal convoluted tubule mitochondrial crista
Stage:	Adult

Phenotype Detail

Acknowledgments

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